870677-05-7

DMAPT (870677-05-7) is a water soluble analog of the natural plant product parthenolide (Cat.# 10-2096) which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits NFκB and stimulates the formation of reactive oxygen species which induced the activation of JNK.1 In non-small cell lung cancers DMAPT inhibits NFκB and DNA double-strand break repair.2

DMAPT is a parthenolide derivative that functions as an antileukemic and cytotoxic agents.

1) Shanmugam?et al. (2011),?A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NFκB and generating reactive oxygen species; Int. J. Cancer,?128?2481 2) Estrabrook?et al. (2011),?Inhibition of NF-κB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays; Free Radic. Biol. Med.,?51?2249