863202-33-9

A3AR antagonist 3 (compound 21) is a selective A3 adenosine receptor (A3AR) antagonist with a Ki of 37 nM. A3AR antagonist 3 shows >60-fold selectivity in comparison to A1 and A2A adenosine receptors[1].

hA₃: 37 nM (Ki); hA₁AR: 2.22 μM (Ki); hA_2AAR: 7.73 μM (Ki)

Store at -20°C

[1] Melissa Perreira, et al. "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DOI:10.1021/jm050221l