ChemicalBook CAS DataBase List 859525-02-3

859525-02-3

Name	2-((2-(3-cyclohexyl-3-((1r,4r)-4-propoxycyclohexyl)ureido)thiazol-5-yl)thio)aceticacid
CAS	859525-02-3
Molecular Formula	C21H33N3O4S2
Molecular Weight	455.63
MOL File	859525-02-3.mol

Chemical Properties

density	1.28±0.1 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMSO : 125 mg/mL (274.35 mM; Need ultrasonic)
form	Solid
pka	3.26±0.10(Predicted)
color	Off-white to pale purple
InChIKey	HPGJSAAUJGAMLV-QAQDUYKDSA-N
SMILES	C(O)(=O)CSC1SC(NC(N(C2CCCCC2)[C@@H]2CC[C@@H](OCCC)CC2)=O)=NC=1

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Animal Model:	Nondiabetic fasted rats^[2]
Dosage:	200 mg/kg
Administration:	200 mg/kg, per os (p.o.)
Result:	Did not change the insulin and glucose concentrations in plasma.

Animal Model:	ob/ob mouse model^[2]
Dosage:	75 or 150 mg/kg
Administration:	75 or 150 mg/kg, per day, for 4 weeks
Result:	Reduced the expression of HbA1c, blood glucose concentrations, lactate concentrations and liver glycogen depots. Improved the lipid profile, reduced plasma, liver TG concentrations and the weight gain at the highest dose.

Animal Model:	Gottingen minipigs^[2]
Dosage:	50 mg/kg
Administration:	50 mg/kg, per day, for 13 weeks
Result:	Eliminated the blood glucose excursion in Minipigs.