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3-(1-Pyrrolidinyl)benzaldehyde is used as a reactant in the preparation of rhodanine derivatives as protease inhibitors against bacterial toxins.

To a stirred solution of 1-(3-(1,3-dioxolan-2-yl)phenyl)pyrrolidine (0.15 g, 0.68 mmol) in THF (5 mL) was added 1N HCl (3 mL) at 0 °C under nitrogen atmosphere. The resulting reaction mixture was warmed to room temperature and stirred for 4 hours. The pro