3-Deoxyaphidicolin exhibits phytotoxic efficacy, that inhibits root growth of lettuce seedlings. 3-Deoxyaphidicolin also exhibits leishmanicidal activity against Leishmania major and Leishmania braziliensis[1][2].
Biological Activity
Inhibitor of eukaryotic DNA synthesis. Mycotoxin. Phytotoxic and cytotoxic agent. Specific inhibitor of DNA polymerase alpha.
storage
+4°C
References
[1] Haraguchi T, et al., Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase alpha, 3-deoxyaphidicolin and aphidicolin-17-monoacetate. Nucleic Acids Res. 1983 Feb 25;11(4):1197-209. DOI:10.1093/nar/11.4.1197 [2] Santos G B, et al., The semisynthetic landscape of aphidicolin: inspiration towards leishmanicidal compounds[J]. Journal of the Brazilian Chemical Society, 2014, 25: 1885-1899.
