Uses
CYM-5482 is a potent and selective agonist Sphingosine 1-phosphate receptor 2 (S1PR2) with an IC50 and EC50 of 1.0 and 1.03 μM. CYM-5482 has the potential for the research of cancer diseases[1].
Definition
ChEBI: 1-[2-[2,5-dimethyl-1-(phenylmethyl)-3-pyrrolyl]-2-oxoethyl]pyrrolidine-2,5-dione is an aromatic ketone.
Biological Activity
ml-031 is an agonist of s1p2 with ec50 value of 1 μm [1].sphingosine 1-phosphate (s1p) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as cell proliferation, migration, survival, and differentiation [1]. sphingolipids belong to a family of bioactive molecules with cell signaling properties. sphingosine 1-phosphate (s1p) is widely expressed on various tissues and cell types. s1p is a pleiotropic lysophospholipid mediator exists in plasma and is released in large amounts from activated platelets [1]. until now, five sphingosine-1-phosphate receptors (s1pr1-s1pr5) have been identified. s1pr4 and s1pr5 are prominently expressed in the immune and nervous systems, respectively. s1p functions by binding to five distinct g protein-coupled receptors, s1p1/edg-1, s1p2/edg-5, s1p3/edg-3, s1p4/edg-6, and s1p5/edg-8.ml-031 activated s1p2 with an ec50 value of 1 μm in a s1p reporter assay [1].
References
[1] satsu h, schaeffer m t, guerrero m, et al. a sphingosine 1-phosphate receptor 2 selective allosteric agonist[j]. bioorganic & medicinal chemistry, 2013, 21(17): 5373-5382.
