849909-77-9

Name	2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)-
CAS	849909-77-9
Molecular Formula	C19H21FN2O2
Molecular Weight	328.38
MOL File	849909-77-9.mol

Synonyms

MAO-B-IN-5 MAO B IN 5,MAOBIN5 2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)-

show less show more

Chemical Properties

Boiling point	509.2±50.0 °C(Predicted)
density	1.237±0.06 g/cm3(Predicted)
pka	16.07±0.20(Predicted)

Hazard Information

Uses

MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 μM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD)[1].

in vivo

MAO-B-IN-5 (1 mg/kg, i.v.; 5 mg/kg, p.o.) shows oral bioavailability in rats (F=13.6%)^[1].
Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats^[1].

Compound	Route	Dose (mg/kg)	C_max (ng/mL)	AUC_t (ng·h/mL)	T_1/2 (h)	Vss (h)	Cl (mL/min/kg)	F (%)
D0	iv	1	809	347	0.37	1.11	47.1	/
	po	5	163	284	1.27	/	/	16.3

SD rats; 1 mg/kg, i.v.; 5 mg/kg, p.o.^[1].

Animal Model:	SD rats^[1]
Dosage:	1, 5 mg/kg
Administration:	1 mg/kg, i.v.; 5 mg/kg, p.o.
Result:	Showed oral bioavailability in rats (F=16.3%).

IC 50

MAO-B: 34.190 μM (IC₅₀); MAO-A: 0.204 μM (IC₅₀)

References

[1] Wang Z,et al. Enhancing monoamine oxidase B inhibitory activity via chiral fluorination: Structure-activity relationship, biological evaluation, and molecular docking study. Eur J Med Chem. 2022; 228:114025. DOI:10.1016/j.ejmech.2021.114025

Spectrum Detail

2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)-(849909-77-9)¹HNMR

Supplier

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Shanghai Amole Biotechnology Co., Ltd.

Telephone13370042665 18916960931

Websitehttps://www.amole.com.cn/

Related Products

20283-92-5 156-51-4

136236-51-6 548-04-9

61-73-4 41372-20-7

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy