VUF-10214 is a H4 receptor-ligand. In vivo studies in the rat reveal that VUF-10214 has significant anti-inflammatory properties in the carrageenan-induced paw-edema model.
Uses
VUF 10214 is a H4 receptor ligand with a pKi of 8.25. VUF 10214 exhibits significant anti-inflammatory activity in a carrageenan-induced paw edema rat model and can be used for research in the field of inflammatory diseases[1].
IC 50
H4 receptor: 8.25 (pKi)
References
[1] Smits RA, et al. Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. J Med Chem. 2008 Apr 24;51(8):2457-67. DOI:10.1021/jm7014217
