59-33-6

White crystals or powder. Melting point 100-101°C. Bitter saline taste. An antihistaminic medicine.

PYRILAMINE MALEATE(59-33-6) is an acidic salt of an amine. Usually does not react as either oxidizing agents or reducing agents but such behavior is not impossible. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Water soluble.

SYMPTOMS: Symptoms of exposure to this compound may include drowsiness, potentiation of the sedative effect of barbituates, fatigues, vertigo, incoordination, tremor, muscle weakness, dryness of the mouth and throat, tinnitus, pupillary dilation, blurred vision, urinary retention, impotence, epigastric and intestinal pain, anorexia, nausea, vomiting, diarrhea, excitation, euphoria, insomnia, nervousness, palpitation, tachycardia, hypotension, hypersensitivity reactions, respiratory depression, coma and delirium.

Flash point data for this chemical are not available, however PYRILAMINE MALEATE is probably combustible.

Mepyramine is a first generation antihistamine that acts as an inverse agonist at the histamine H₁ receptor. It is reported to bind with high affinity to a G_q/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H₁ receptor that interferes with the G_q/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway. Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC₅₀ value of -7.94.

solid

A histamine H1 receptor antagonist

Mepyramine maleate is used as bulk pharmaceutical (antihistaminic). Product Data Sheet

Pyrilamine maleate Selective inverse agonist for the H-1 histamine receptor. Pyrilamine Maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. And also used to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.

Histavet-P [Veterinary] (Schering-Plough Animal Health); Pymafed (HoechstRoussel).

Selective inverse agonist for the H 1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters G q/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

Pyrilamine maleate is a H1 histamine receptor antagonist. Pyrilamine maleate induces sleep in vertebrates. In Cassiopea, it induces concentration dependent dormancy.

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects; predominantly used in horses.

4°C, protect from light