ChemicalBook CAS DataBase List 848035-21-2

848035-21-2

Name	Compound 48/80 (hydrochloride)
CAS	848035-21-2
Molecular Formula	C32H48Cl3N3O3
MDL Number	MFCD04108752
Molecular Weight	629.101
MOL File	848035-21-2.mol

Chemical Properties

storage temp.	Store at -20°C, sealed storage, away from moisture ,protect from light
solubility	Water: 100 mM
form	A solid
color	White to off-white

Safety Data

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301+H311+H331
Precautionary statements	P261-P264-P270-P271-P280-P301+P310-P321-P330-P302+P352-P304+P340-P311-P312-P361+P364-P403+P233-P405-P501

Hazard Information

Uses

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets [1][2][3].

Biological Activity

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde condensation products. It is also a histamine releaser and mast cell degranulator. It inhibits the activity of phosphatidylinositol-specific phospholipase C in human platelets.

in vitro

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC ₅₀ values are 2.1 μg/ml (supernatant ) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80.

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in vivo

Compound 48/80 trihydrochloride (0.75 mg/kg; ip; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter.
Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation.

Animal Model:	7-week-old Wistar male rats (fasted for 24 hours)
Dosage:	0.75 mg/kg
Administration:	Intraperitoneal injection; Killed after 0.5, 3 or 6 h
Result:	Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin conc entrations in rats decreased time-dependently thereafter.

storage

Store at -20°C, sealed storage, away from moisture ,protect from light

References

[1] Bronner C, et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys Acta. 1987 Aug 15;920(3):301-5. DOI:10.1016/0005-2760(87)90108-1
[2] Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. DOI:10.1371/journal.pone.0052104
[3] Kaida S, et al. Compound 48/80 causes oxidative stress in the adrenal gland of rats through mast cell degranulation. Free Radic Res. 2010 Feb;44(2):171-80. DOI:10.3109/10715760903380466

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