Description
Phosphatidylinositols are glycerophospholipids that contain a glycerol backbone, two non-polar fatty acid tails, and a polar inositol head group.
1,2 They are synthesized from cytidine diphosphate diacylglycerol (CPD-DAG) and myoinositol by phosphoinositol synthase and represent approximately 10% of total cellular phospholipids. Phosphatidylinositols can be phosphorylated on their inositol rings to produce phosphoinositides, which have been implicated in calcium regulation, vesicle trafficking, mitogenesis, cell survival, and rearrangement of actin. This product contains phosphatidylinositol molecular species with primarily C16:0 and C18:0 fatty acyl chain lengths.
References
1. De Craene, J.-O., Bertazzi, D.L., B?r, S., et al. Phosphoinositides, major actors in membrane trafficking and lipid signaling pathways Int. J. Mol. Sci. 18(3),E634(2017).
2. Tolias, K.F., and Cantley, L.C. Pathways for phosphoinositide synthesis Chem. Phys. Lipids 98(1-2),69-77(1999).
