847727-81-5

AAT-008 is an antagonist for the PGE2 receptor EP4.

AAT-008 is a potent, selective, and orally active prostaglandin EP4 receptor antagonist with Kis of 0.97 and 6.1 nM for recombinant human EP4 and recombinant rat EP4, respectively[1].

EP4: 0.97 nM (Ki); EP4: 6.1 nM (IC₅₀)

Store at -20°C

[1] Okumura Y, et al. Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist. Bioorg Med Chem Lett. 2017;27(5):1186-1192. DOI:10.1016/j.bmcl.2017.01.067