847554-50-1

Name	RTI-118
CAS	847554-50-1
Molecular Formula	C26H32N4O3
MDL Number	MFCD30536600
Molecular Weight	448.56
MOL File	847554-50-1.mol

Synonyms

RTI-118 3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxamide, tetrahydro-3-oxo-1,1-diphenyl-N-[2-(1-piperidinyl)ethyl]-

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Chemical Properties

Boiling point	720.0±60.0 °C(Predicted)
density	1.28±0.1 g/cm3(Predicted)
pka	13.93±0.40(Predicted)

Hazard Information

Uses

RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve agent addiction including selectively decrease self-administration[1].

in vivo

RTI-118 (5-30 mg/kg, intraperitoneal injection; pre-30 minutes) is well tolerated in rats with no significant outward signs of aversion, sedation or toxicity, it also produces a dose-related decrease in food self-administration^[1].

Animal Model:	Rat^[1]
Dosage:	5 mg/kg; 10 mg/kg; 20 mg/kg; 30 mg/kg
Administration:	Intraperitoneal?injection; pre-treatment 30 minutes; 5-30 mg/kg
Result:	The effects on the reinstatement of seeking behavior are restricted to doses of 20 mg/kg or less.

References

[1] Schmoutz CD, et al.Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats.Pharmacol Biochem Behav. 2012 Dec;103(2):332-7. DOI:10.1016/j.pbb.2012.09.003
[2] Bonano JS,et al. Effects of the neuropeptide S receptor antagonist RTI-118 DOI:10.1016/j.ejphar.2014.09.006

Supplier

Fan De(Beijing) Biotechnology Co., Ltd.

Telephone 15911056312

Websitehttp://www.bio-fount.com/

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