Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Enalaprilat is the active metabolite of enalapril (Item No.
16041), an ACE inhibitor with roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.
1. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized
in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC
50 value of 5.8 nM
in vitro.
2