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Cascara sagrada is one of the mildest of the anthraquinone-containing laxatives. Phenolphthalein is partially absorbed (about 15% of a given dose) and excreted into the bile; hence, if it is taken constantly, it will accumulate and exert too drastic an action. It inhibits active sodium and glucose absorption in the bowel.Once widely available in many over-the-counter products, it was pulled from the market when it was linked to cancer.