ChemicalBook CAS DataBase List 845932-30-1

845932-30-1

Name	KU59403
CAS	845932-30-1
Molecular Formula	C29H32N4O4S2
Molecular Weight	564.72
MOL File	845932-30-1.mol

Chemical Properties

Boiling point	814.3±65.0 °C(Predicted)
density	1.368±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
pka	13.73±0.20(Predicted)
color	White to yellow

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Fan De(Beijing) Biotechnology Co., Ltd.

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Chengdu Peter-like Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Shanghai Tachizaki Biomedical Research Center

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Nantong QuanYi Biotechnology Co., Ltd

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RD International Technology Co., Limited

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Shanghai Amole Biotechnology Co., Ltd.

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Shanghai Anbida Biotechnology Co., Ltd.

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Animal Model:	CD-1 nude mice implanted with SW620 or HCT116-N7 human cancer cell lines at 1×10⁷ cells per animal s.c. (n=5 per group)^[1].
Dosage:	6, 12.5 and 25 mg/kg.
Administration:	I.P. twice daily (0 and 4 hours) and 12.5 mg/kg once daily.
Result:	Treatment with BMY-40481 alone causes a modest tumour growth delay of 4 days (time to RTV4=10.5 days). This delay is extended to 8.5 days when given with KU 59403 at 12.5 mg/kg i.p. twice daily for 5 days and 11.5 days (time to RTV4=18 days) when given with KU 59403 at 25 mg/kg i.p. twice daily for 5 days.

845932-30-1

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Spectrum Detail

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