ChemicalBook CAS DataBase List 82857-38-3

82857-38-3

Name	Wandonorm
CAS	82857-38-3
Molecular Formula	C26H32N2O7
MDL Number	MFCD00798228
Molecular Weight	484.541
MOL File	82857-38-3.mol

Chemical Properties

storage temp.	Store at -20°C
solubility	Water: 5mM
form	White solid.

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H332-H302
Precautionary statements	P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501

Hazard Information

Uses

Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a proagent of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research.

Definition

ChEBI: Bopindolol malonate is a benzoate ester.

in vivo

Bopindolol (intravenous injection; 8, 16 and 32 μg/kg) causes a dose-dependent inhibition of isoprenaline-induced tachycardia, and this agent is 4 times more potent than propranolol in anaesthetised dogs^[1]. Bopindolol (0.3, 1 and 3 mg/kg; IP; single dosage) produces dose dependent decreases in diastolic blood pressure and in heart rate^[2].

Animal Model:	Male Wistar rats (260-300 g)^[2]
Dosage:	0.3, 1 and 3 mg/kg
Administration:	IP; single dosage
Result:	Produced dose dependent decreases in diastolic blood pressure, and the decrease of about 8 mmHg at 3 mg/kg. Decreased the heart rate in a dose-dependent manner.

storage

Store at -20°C

References

[1] Harron DW, et al. Bopindolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs. 1991 Jan;41(1):130-49. DOI:10.2165/00003495-199141010-00010
[2] H Tanaka, et al. Hypotensive effect of bopindolol in pithed rats. Gen Pharmacol. 1993 Mar;24(2):373-5. DOI:10.1016/0306-3623(93)90319-s
[3] Y Hosohata, et al. Bopindolol is a slowly dissociating beta 1-adrenoceptor antagonist when compared to other beta-blockers. Biol Pharm Bull. 1995 Aug;18(8):1066-71. DOI:10.1248/bpb.18.1066
[4] Nagatomo T, et al. Bopindolol: pharmacological basis and clinical implications. Cardiovasc Drug Rev. 2001 Spring;19(1):9-24. DOI:10.1111/j.1527-3466.2001.tb00180.x

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