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Bixlozone is a herbicide used to control problematic grasses and broadleaved weeds in a wide range of crops. It is moderately soluble in water and is not highly volatile. Depending on local conditions it can be moderately persistent in soils. It is hydrolytically stable. It is moderately toxic to birds. Bixlozone has a low oral mammalian toxicity.

Bixlozone is used as a herbicidal composition containing trifludimoxazin and weed control method.

ChEBI: Bixlozone is an oxazolidinone that is 1,2-oxazolidin-3-one substituted by a 2,4-dichlorobenzyl group at position 2 and two methyl groups at position 4. It is a herbicide used for the control of annual ryegrass (including herbicide resistant biotypes) and regionally specific broadleaf weeds. It has a role as a herbicide, an agrochemical and a carotenoid biosynthesis inhibitor. It is an oxazolidinone and a dichlorobenzene.

Bixlozone is manufactured through a modular, heterocycle-assembly route characteristic of modern isoxazoline herbicides. Producers began by constructing the isoxazoline core from appropriately functionalised precursors, typically a halogenated or activated nitrile paired with an oxime type partner, under conditions that promoted cyclisation without over reaction of the sensitive heterocycle. In parallel, the heavily chlorinated and difluoromethyl-substituted aromatic fragment was prepared using established electrophilic substitution chemistry, with careful control of temperature to avoid decomposition of the difluoromethyl group. These fragments were then joined through a selective bond-forming step, often an amide-type or heteroaryl coupling, chosen to preserve the integrity of both the isoxazoline ring and the fluorinated aromatic system.

Both systemic and contact activity. Uptake is predominantly via roots and young shoots. Bleaching - Carotenoid biosynthesis inhibitor.

Herbicide