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Complement factor H (CFH) is a plasma regulator of the complement protein C3b in the alternative pathway of the complement system. Research has shown that binding of CFH is important for pathogenesis of group A streptococcus (GAS), and inhibition of this binding may be an effective management of GAS infections.

Complement factor H plays an essential role in the homeostasis of the complement system and in preventing collateral damage to bystander cells and tissues by complement activation.