800394-83-6

D-87503 is a potent inhibitor of PI3k/Akt/mTOR, with the IC50s of 62 nM and 0.76 μM, respectively for PI3k and Erk2. D-87503 effectively suppressed the target downstream substrates Akt and Rsk1 kinase of the PI3k/Akt/mTOR signaling pathway[1].

[1] Mukesh Chandra Joshi, et al. Potent Phosphatidylinositol 3-Kinase Inhibitors and Their Biology. Review Curr Drug Discov Technol. 2014 Jun;11(2):113-26. DOI:10.2174/1570163810666131229130207