78996-15-3

13-cis Retinoic acid-d₅ is intended for use as an internal standard for the quantification of 13-cis retinoic acid by GC- or LC-MS. 13-cis Retinoic acid is a naturally occurring retinoid that inhibits retinol oxidation and dehydrogenation of 17β-hydroxy steroids.

An endogenous retinoic acid isomer, which is capable of binding to both retinoic acid receptors (RAR) and retinoid X receptors (RXR). A biologically active ligand for members of the RAR and RXR subfamilies, implying that it may play a critical role in regulating retinoid-responsive pathways.

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[1] PHD W S B. Cellular metabolism and actions of 13-cis-retinoic acid[J]. Journal of the American Academy of Dermatology, 2001, 45 5: Pages S129-S135. DOI: 10.1067/mjd.2001.113714