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11-Oxahomoaminopterin shows antifolate activity and inhibits Lactobacillus casei DHFFZ with antimicrobial and antitumor activities[1].

[1] Nair MG, et al. Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds. J Med Chem. 1981 Sep;24(9):1068-73. DOI:10.1021/jm00141a010