Uses
RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
IC 50
T1-CDK9: 1 nM (IC50); cyclin B1-CDK1: 2 nM (IC50); cyclin E-CDK2: 3 nM (IC50); cyclin D1-CDK4: 4 nM (IC50); cyclin E-CDK3: 5 nM (IC50); p35-CDK5: 5 nM (IC50); cyclin H-CDK7: 44 nM (IC50); cyclin D3-CDK6: 55 nM (IC50); GSK-3β: 3 nM (IC50); JAK2: 50 nM (IC50); MEK1: 54 nM (IC50); Fms: 1 nM (IC50); TAK1: 5 nM (IC50); JNK1a1: 17 nM (IC50); JNK1a2: 40 nM (IC50); C-src: 25 nM (IC50); AMPK: 41 nM (IC50)