A-49816 is an orally active diuretic that increases urine volume and sodium and chloride excretion. A-49816 at high doses (12.5, 15, and 20 mg) caused significant salt and chloride excretion and diuresis in experimental animals[1].
References
[1] Luther RR, et al. Pharmacologic effects of A-49816, a new high-ceiling diuretic. J Clin Pharmacol. 1987 Oct;27(10):794-801. DOI:10.1002/j.1552-4604.1987.tb02999.x
