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3-Chloro-4-methylaniline hydrochloride is a chemical compound that can be found in the environment and in certain foods. It is an inhibitor of the receptor activity of acetylcholine, which has been shown to have a number of effects on the body. 3-Chloro-4-methylaniline hydrochloride has been shown to cause liver lesions in rats and also causes a decrease in glomerular filtration rate (GFR). The compound has been shown to inhibit transfection experiments with rat tubule cells, and it has been shown to inhibit water vapor absorption at physiological levels. 3-Chloro-4-methylaniline hydrochloride has also been shown to affect energy metabolism by decreasing the amount of glucose taken up by insulin by the liver, as well as increasing blood pressure and heart rate.

Corrosive to skin and eyes of rabbits. A mild to moderate skin sensitizer in guinea pigs. No evidence of carcinogenicity in 78-week studies of rats and mice (conducted by the National Cancer Institute). Causes lung changes, hypoglycemia, and methemoglobinemia in intraperitoneal lethal-dose studies of chickens. Causes methemoglobinemia in intraperitoneal lethal-dose studies of mice. A skin and strong eye irritant. Harmful by ingestion, inhalation, and skin absorption. Prolonged or repeated exposure may be harmful.