76041-71-9

33252-63-0

76041-71-9

General procedure for the synthesis of 3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine from 2-hydroxy-5-(trifluoromethyl)pyridine: 2-hydroxy-5-(trifluoromethyl)pyridine (15.3 g, 0.094 mol) and N-chlorosuccinimide (14.4 g, 0.108 mol) were dissolved in 50 mL of anhydrous N,N-dimethylformamide (DMF) and nitromethane in a in a mixed solvent. The reaction mixture was stirred at room temperature for 8 hours. After the reaction was completed, the reaction solution was slowly poured into 250 mL of water and a light yellow precipitate was precipitated. The precipitate was collected by filtration and dried to give 17.1 g (0.087 mol) of 3-chloro-5-trifluoromethyl-2-hydroxypyridine in 92% yield.