757950-09-7

Name	Raseglurant
CAS	757950-09-7
Molecular Formula	C15H13FN2
MDL Number	MFCD18785292
Molecular Weight	240.28
MOL File	757950-09-7.mol

Synonyms

Raseglurant Raseglurant/ADX-10059 2-((3-Fluorophenyl)ethynyl)-4,6-dimethylpyridin-3-amine 2-(3-Fluoro-phenylethynyl)-4,6-dimethyl-pyridin-3-ylamine 2-[2-(3-fluorophenyl)ethynyl]-4,6-dimethyl-3-Pyridinamine 3-Pyridinamine, 2-[2-(3-fluorophenyl)ethynyl]-4,6-dimethyl-

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Chemical Properties

Boiling point	431.2±45.0 °C(Predicted)
density	1.20±0.1 g/cm3(Predicted)
pka	4.18±0.37(Predicted)

Hazard Information

Uses

Raseglurant (ADX-10059) is a mGlu5 receptor negative allosteric modulator. Raseglurant is effective against migraine. Raseglurant reduces the Haloperidol (HY-14538)-induced catalepsy in mice[1][2].

References

[1] Romero-Fernandez W, et al. The mGlu5 Receptor Protomer-Mediated Dopamine D2 Receptor Trans-Inhibition Is Dependent on the Adenosine A2A Receptor Protomer: Implications for Parkinson's Disease. Mol Neurobiol. 2022 Oct;59(10):5955-5969. DOI:10.1007/s12035-022-02946-9
[2] Font J, et al. Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator. Elife. 2018 Jan 8;7:e34752. DOI:10.7554/eLife.34752

Supplier

Suzhou Rovathin Foreign Trade Co.,Ltd

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Websitehttp://www.rovathin.com/

Wuhan Yuxiang Medical Technology Co., Ltd.

Telephone 13971275651

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1155268/0.htm

Nantong QuanYi Biotechnology Co., Ltd

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Hangzhou MolCore BioPharmatech Co.,Ltd.

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