ChemicalBook CAS DataBase List 756875-51-1

756875-51-1

Name	K6PC-5
CAS	756875-51-1
Molecular Formula	C19H37NO4
MDL Number	MFCD30480923
Molecular Weight	343.5
MOL File	756875-51-1.mol

Chemical Properties

Boiling point	555.3±50.0 °C(Predicted)
density	1.007±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: 30 mg/ml
form	A solid
pka	12.57±0.59(Predicted)
color	White to off-white
Cosmetics Ingredients Functions	SKIN PROTECTING
InChIKey	CGYVFCHCRBGGJG-UHFFFAOYSA-N
SMILES	O=C(CCCCCCC)C(CCCCCC)C(NC(CO)CO)=O

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319
Precautionary statements	P264-P280-P305+P351+P338-P337+P313
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2

Hazard Information

Uses

K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research[1][2][3].

Biological Activity

K6PC-5 is a potent and selective sphingosine kinase 1 (SphK1 or SK1) activator th at increases keratin 1 and involucrin expression in normal human epidermal keratinocytes cultured in vitro. K6PC-5 promotes differentiation and proliferation of keratinocytes via intracellular Ca2+ signaling.

in vivo

In intrinsically aged hairless mice (56 weeks old), 1% K6PC-5 is applied topically for 2 weeks. This K6PC-5 treatment significantly increases both the number of dermal fibroblasts and collagen production. As a consequence, dermal thickness also increased significantly^[2].

Animal Model:	Intrinsically aged hairless mice (56 weeks old)^[2]
Dosage:	1% (vehicle (PEG:EtOH = 7:3))
Administration:	Topical application; twice daily for 2 weeks
Result:	Enhanced fibroblast proliferation, collagen production, and eventually increased dermal thickness.

IC 50

SphK1; EBOV

References

[1] Kwon YB, et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48(9):1936-43. DOI:10.1194/jlr.M700185-JLR200
[2] Jong-Kyung Youm, et al. K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling. J Dermatol Sci. 2008 Aug;51(2):89-102. DOI:10.1016/j.jdermsci.2008.03.002
[3] Imre G, et al. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection. iScience. 2021 Mar 5;24(4):102266. DOI:10.1016/j.isci.2021.102266

Spectrum Detail

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