ChemicalBook CAS DataBase List 756525-99-2

756525-99-2

Name	alpha-MaleiMidopropionyl-oMega-succiniMidyl-4(ethylene glycol)
CAS	756525-99-2
EINECS(EC#)	201-258-5
Molecular Formula	C22H31N3O11
MDL Number	MFCD11041113
Molecular Weight	513.49
MOL File	756525-99-2.mol

Synonyms

N-Succinim Mal-PEG4-NHS Mal-NH-PEG4-NHS Mal-amido-PEG4-NHS MAL-DPEG4-NHS Ester Mal-NH-PEG4-NHS ester MAL-NH-PEG4-CH2CH2COONHS Maleimide-PEG4-NHS Ester Maleimide-PEG4-succinimidyl Ester Maleimide-NH-PEG4-CH2CH2COONHS Ester Maleimidopropionyl-PEG4-CH2CH2COONHS Ester alpha-MaleiMidopropionyl-oMega-succiniMidyl-4(ethylene glycol) 3-(2-Maleimidoethylcarbamoyl)-peg4-propionic acid N-hydroxysuccinimide ester O-[N-(3-MaleiMidopropionyl)aMinoethyl]-O′-[3-(N-succiniMidyloxy)-3-oxopropyl]triethylene glycol O-[N-(3-Maleimidopropionyl)aminoethyl]-O'-[3-(N-succinimidyloxy)-3-oxopropyl]triethylene glycol >=90% (NMR) 2,5-dioxopyrrolidin-1-yl 19-(2,5-dioxo-2H-pyrrol-1(5H)-yl)-17-oxo-4,7,10,13-tetraoxa-16-azanonadecan-1-oate 2,5-dioxopyrrolidin-1-yl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16-tetraoxa-4-azanonadecan-19-oate N-[15-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]-2,5-dihydro-2,5-dioxo-1H-pyrrole-1-propanamide 4,7,10,13-Tetraoxa-16-azanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo-, 2,5-dioxo-1-pyrrolidinyl ester

Chemical Properties

density	1.36±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO
form	Solid
pka	15.01±0.46(Predicted)
color	White to off-white
InChI	InChI=1S/C22H31N3O11/c26-17(5-8-24-18(27)1-2-19(24)28)23-7-10-33-12-14-35-16-15-34-13-11-32-9-6-22(31)36-25-20(29)3-4-21(25)30/h1-2H,3-16H2,(H,23,26)
InChIKey	XSRYGQJQNPJNKZ-UHFFFAOYSA-N
SMILES	C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
HS Code	2928009090
Storage Class	10 - Combustible liquids

Hazard Information

Description

Mal-amido-PEG4-NHS is a PEG linker containing a maleimide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

Maleimide-PEG4-NHS (CAS# 756525-99-2) is a cross-linking compound used in the lysosomal acid-triggered release of anticancer drugs.

General Description

Maleimide-PEG4-NHS Ester (CAS 756525-99-2) is a high-purity, monodisperse polyethylene glycol (PEG) derivative. Its synonyms include Mal-amido-PEG4-NHS, Mal-amido-PEG4-NHS ester, Mal-NH-PEG4-NHS, MAL-NH-PEG4-NHS ESTER and Mal-NH-PEG4-CH₂CH₂COONHS, amongst others. This compound possesses three key functional groups: the Mal group, the PEG4 chain and the NHS ester. The Mal group is capable of forming covalent bonds with thiol groups without affecting the overall structure of the protein; the NHS ester enhances reactivity with primary amine groups, facilitating the formation of stable amide bonds; whilst PEG4 improves the hydrophilicity and biocompatibility of the conjugate, whilst also reducing aggregation and immunogenicity. Consequently, this substance is primarily used in the synthesis of protein conjugates, drug delivery research, diagnostic testing and materials science.

reaction suitability

reagent type: cross-linking reagent

IC 50

PEGs; Alkyl/ether

Questions And Answer

Spectrum Detail

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