749234-11-5

DMAT is a cell-permeable inhibitor of casein kinase 2 (CK2; IC₅₀ = 0.13 μM). It also inhibits Pim-1, Pim-3, HIPK2, and HIPK3 (IC₅₀s = 0.15, 0.097, 0.37, and 0.59 μM, respectively). DMAT blocks cell growth and induces cell death in cancer cells, both in culture and in mouse xenografts.

2-Dimethylamino-4,5,6,7-tetrabromobenzimidazole is a novel powerful and selective inhibitor of protein kinase CK2.

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