ChemicalBook CAS DataBase List 73604-30-5

73604-30-5

Name	(-)-BICUCULLINE METHOBROMIDE
CAS	73604-30-5
Molecular Formula	C21H20BrNO6
MDL Number	MFCD00055149
Molecular Weight	462.29
MOL File	73604-30-5.mol

Chemical Properties

storage temp.	2-8°C
solubility	aqueous base: unstable
form	solid
color	white
Water Solubility	Soluble in water (50mM)
Sensitive	Light Sensitive

Safety Data

Safety Statements	24/25 less more
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
HazardClass	6.1(b)
PackingGroup	III

Hazard Information

Uses

(-)-Bicuculline methobromide is an N-methylated derivative of the GABAA?antagonist bicuculline.

Biological Activity

Methobromide salt of (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

in vivo

(-)-Bicuculline methobromide can be used in animal modeling to create epilepsy models and is capable of crossing the blood-brain barrier^[3].

1. Induction of epilepsy^[3]

Background

(-)-Bisculline methoromide can inhibit the synthesis and release of GABA, and weaken GABA's inhibition of neuronal activity in the SN reticular region (SNr), leading to epilepsy.

Specific Mmodeling Methods

Rat: Sprague-Dawley (SD) ? male or female ? 2 weeks old
Administration: 12.5, 25, 50 or 100 ng/0.25 μL ? inject into SN or corpus striatum through bilateral catheter implantation

Note

(1) Dissolve (-)-Bicuculine methoromide in distilled water and administer at a volume of 0.25 μL.
(2) Simultaneously administer bilateral infusions at a rate of 0.25 μ L/min, and after the infusion is completed, insert the catheter in situ for an additional minute to prevent drug reflux.
(3) Due to the short-lived effect of (-) - Bicuculine methoromide in SN, rats were tested 5 minutes after completing the infusion.

Modeling Indicators

Behavioral observation: Shortened the latency period of epileptic seizures, causing stereotyped behaviors such as excessive sniffing or licking, chewing movements, head twitching, and slow or occasional circling.

Correlated Product(s): Muscimol (HY-N2313)

Opposite Product(s): /

Animal Model:	Rat L5-SNL model^[2]
Dosage:	0.6 nmol/rat
Administration:	Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.)
Result:	Attenuated the antiallodynic effect of Neurotropin.

storage

Store at 2-8°C

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