73565-87-4

Hydrocortisone-d₄ is intended for use as an internal standard for the quantification of hydrocortisone/cortisol by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson''s disease.

White Solid

Anti-inflammatory hormone

Labelled Cortisol (H714615). Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.

Cortisol, also known as hydrocortisone, is a glucocorticoid produced by the adrenal gland. This stable labeled internal standard is suitable for quantitation of cortisol levels in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing′s syndrome, Addison′s disease, and Sheehan′s syndrome.

[1] KRIEGER D T. Rhythms of acth and corticosteroid secretion in health and disease, and their experimental modification[J]. Journal of steroid biochemistry, 1975, 6 5: Pages 785-791. DOI: 10.1016/0022-4731(75)90068-0
[2] BOADIE W. DUNLOP  Andrea W. The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions[J]. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2019, 89: Pages 361-379. DOI: 10.1016/j.pnpbp.2018.10.010
[3] PAUL M. STEWART  Christopher R W E. The cortisol-cortisone shuttle and hypertension[J]. Journal of Steroid Biochemistry and Molecular Biology, 1991, 40 4: Pages 501-509. DOI: 10.1016/0960-0760(91)90269-b
[4] FEMINA P. VARGHESE E S B. The Hypothalamic-Pituitary-Adrenal Axis in Major Depressive Disorder: A Brief Primer for Primary Care Physicians.[J]. Primary care companion to the Journal of clinical psychiatry, 2001, 3 4: 151-155. DOI: 10.4088/pcc.v03n0401
[5] NAYRON MEDEIROS SOARES. Cortisol levels, motor, cognitive and behavioral symptoms in Parkinson’s disease: a systematic review.[J]. Journal of Neural Transmission, 2019, 126 3: 219-232. DOI: 10.1007/s00702-018-1947-4