73196-97-1

Name	dactimicin
CAS	73196-97-1
Molecular Formula	C18H36N6O6
MDL Number	MFCD00890168
Molecular Weight	432.518
MOL File	73196-97-1.mol

Synonyms

St 900 Sf-2052 dactimicin Antibiotic SF-2052 Reaxys ID: 1410417 Formimidoyl-fortimicin A 4-Amino-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-1-[[[(iminomethyl)amino]acetyl]methylamino]-6-O-methyl-L-chiro-inositol 4-Amino-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-1-[[[(iminomethyl)amino]acetyl]methylamino]-6-O-methyl-1,4-dideoxy-L-chiro-inositol L-Chiro-inositol, 4-amino-1,4-dideoxy-3-o-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-1-((((iminomethyl)amino)acetyl)methylamino)-6-o-methyl-

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Hazard Information

Description

Dactimicin is a a novel pseudodisaccharide aminoglycoside. It activities in vitro and in vivo antibacterial compared with those of other aminoglycoside antibiotics. Dactimicin was more resistant than astromicin to inactivation by aminoglycoside 3-acetyltransferase, probably owing to the protective action of the formimidoyl group.

Uses

Dactimicin is a pseudodisaccharide aminoglycoside. Dactimicin is an antibiotic that can inhibit the growth of methicillin-susceptible S. aureus isolates and coagulase-negative staphylococci with MIC50s of 2 μg/mL. Dactimicin is active against organisms possessing aminoglycoside-modifying enzymes[1].

References

[1] Gu JW, et al. In vitro activity of dactimicin, a novel pseudodisaccharide aminoglycoside, compared with activities of other aminoglycosides. Antimicrob Agents Chemother. 1989 Nov;33(11):1998-2003. DOI:10.1128/AAC.33.11.1998

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