71965-46-3

Active human cathepsin S is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Active human cathepsin S has been used in a study to assess the pathogenesis of Alzheimer′s disease. Active human cathepsin S has also been used in a study to investigate the optimization of selectivity of Azepanone-based inhibitors.

Human cathepsin S (GenBank Accession No. NM_004079.3), CD33 signal peptide(amino acids 1-16) + cathepsin S (amino acids 17-331), with C-terminal HIS tag, MW = 37 kDa, expressed in FreeStyle 293-F cells.

Cathepsin Sas a lysosomal proteasefacilitates the breakdown of unwanted and damaged proteins in the endo-lysosomal pathway. Moreoverit plays specific rolessuch as contributing to major histocompatibility complex (MHC) class II antigen presentation by aiding in the degradation of the invariant chain. Dysregulation of cathepsin S has been associated with various pathological conditionssuch as cancerarthritisand cardiovascular disease. Cathepsin S is useful for the study of enzyme kineticsscreening inhibitorsand selectivity profiling. It is also used as a biomarker for atherosclerosisdiabetesadiposityand atherogenesis. Moreoverit acts as a promising target against brain-penetrating and for the treatment of multiple sclerosis and neuropathic pain.