71831-09-9

Avermectin B_1a monosaccharide is a macrolide anthelmintic and monosaccharide form of avermectin B_1a . It is lethal to C. elegans with a minimum active concentration (MAC) value of 0.1 μM. Avermectin B_1a monosaccharide also stimulates conductance in isolated shore crab muscle.

Avermectin monosaccharide is an acid degradation product produced by selective hydrolysis of the terminal saccharide unit of avermectin. Avermectin monosaccharide is a potent inhibitor of nematode larval development, but is devoid of paralytic activity. Despite the importance of avermectin as an anthelmintic in animal health, there are few published reports of the biological activity or the levels of avermectin monosaccharide in animals or in the environment.

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[1] JERRY W. BOWMAN . Effects of dihydroavermectin B1a and analogs on stretcher muscle of the lined shore crab, Pachygrapsus crassipes[J]. Comparative biochemistry and physiology. C: Comparative pharmacology, 1991, 99 3: Pages 333-340. DOI: 10.1016/0742-8413(91)90251-n