71812-08-3

Herquline A is an alkaloid fungal metabolite originally isolated from P. herquei. It inhibits cell death induced by influenza A strain A/PR/8/34 in MDCK cells with an IC₅₀ value of 10 μg/ml and inhibits viral replication in a plaque assay in a concentration-dependent manner. Herquline A also inhibits platelet aggregation induced by ADP and platelet-activating factor (PAF) in vitro (IC₅₀s = 180 and 240 μM, respectively).

Herquline A is an alkaloid produced by Penicillium herquei. It is an antiviral agent that inhibits influenza virus replication.Herquline A is also a platelet aggregation inhibitor.

[1] Y ENOMOTO. Herquline B, a new platelet aggregation inhibitor produced by Penicillium herquei Fg-372.[J]. Journal of Antibiotics, 1996, 49 1: 50-53. DOI: 10.7164/antibiotics.49.50
[2] TAKUYA CHIBA. Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties[J]. Bioscience, Biotechnology, and Biochemistry, 2017, 24 1: 59-62. DOI: 10.1080/09168451.2016.1162084