ChemicalBook CAS DataBase List 7082-21-5

7082-21-5

Name	N-(4,4-diphenylbutan-2-yl)-2-methyl-propan-2-amine hydrochloride
CAS	7082-21-5
Molecular Formula	C20H28ClN
MDL Number	MFCD00941402
MOL File	7082-21-5.mol

Chemical Properties

Melting point	178-180°
storage temp.	−20°C
solubility	DMSO: >20mg/mL
form	solid
color	white to off-white

Safety Data

Hazard Codes	Xn,N
Risk Statements	22-36-50 less more
Safety Statements	26-61 less more
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS	UH9970000
Toxicity	LD50 oral in rat: 465mg/kg less more

Hazard Information

Uses

Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca2+ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence[1].

Definition

ChEBI:Terodiline hydrochloride is a diarylmethane.

Biological Activity

Terodiline hydrochloride is a non-selective calcium channel antagonist with anticholinergic and vasodilatory activity.''Terodiline is known to increase corrected QT interval (QTc) and decrease resting heart rate in elderly patients. Furthermoreterodiline hydrochloride has been linked to cardiac arrhythmias1.

in vivo

Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID₅₀= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED₅₀=59 mg/kg)^[1].

Animal Model:	Fmale or male Hartley guinea pigs (200-600 g)^[1]
Dosage:	80 mg/kg
Administration:	Administered S.C.
Result:	Yielded an ID₅₀ of 24±6 mg/kg. Higher doses were Iethal.

storage

Store at -20°C

References

[1] Noronha-Blob L, et al. (+/-)-Terodiline: an M1-selective muscarinic receptor antagonist. In vivo effects at muscarinic receptors mediating urinary bladder contraction, mydriasis and salivary secretion. Eur J Pharmacol. 1991 Aug 29;201(2-3):135-42. DOI:10.1016/0014-2999(91)90336-o

Supplier

Related Products

Send Inquriy