69877-38-9

GENERAL METHOD: Sodium carbonate (4.77 g, 45 mmol) and activated manganese dioxide powder (3.91 g, 45 mmol) were added to a vigorously stirred solution of alcohols 27-31 (2.2 mmol) in dichloromethane (45 mL). The resulting suspension was stirred at room temperature until the reaction was complete (monitored by thin layer chromatography) and subsequently filtered through a diatomaceous earth pad. The filtrate was evaporated to dryness to obtain the residue. The residue was purified by fast column chromatography to afford allyl aldehydes 32-36 (only the 2E,4E-isomer was plotted).

[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 2, p. 721 - 737
[2] Chemistry - A European Journal, 2014, vol. 20, # 29, p. 8904 - 8908
[3] Patent: US4169100, 1979, A