6963-65-1

2302-25-2

6963-65-1

Example 312A Synthesis of 5-bromo-4-nitro-1H-imidazole: 4-bromo-1H-imidazole (2.0 g, 13.6 mmol) was mixed with concentrated nitric acid (0.947 mL, 14.96 mmol) in concentrated sulfuric acid (20 mL), and reacted for 1 hr at 110°C. After completion of the reaction, the mixture was cooled to 25 °C and slowly poured into 200 mL of ice water. The precipitated white solid was collected by filtration to give 5-bromo-4-nitroimidazole (2.3 g, 87% yield). Mass spectrum (ESI-) m/z 191 ([M-H]-). 1H NMR (300 MHz, DMSO-d6) δ 7.99 (s, 1H).