Synthesis
General procedure for the synthesis of 5-bromoisobenzofuran-1,3-dione from 5-bromoisobenzofuran-1,3-dione: 5-bromoisobenzofuran-1,3-dione (6.6 g, 30 mmol, 1.0 eq.) was mixed with formamide (10 mL, 240 mmol, 8.0 eq.), and the reaction was stirred for 2 hr at 200 °C. Upon completion of the reaction, the mixture was quenched by pouring it into an ice-water mixture. The precipitated solid product was collected by filtration and dried under vacuum to afford 5-bromoisoindole-1,3-dione (7.0 g, 99% yield). Mass spectrum (ESI): m/z 227 ([M+H]+).
References
[1] Patent: US2010/204214, 2010, A1. Location in patent: Page/Page column 109
[2] Patent: JP5906522, 2016, B2. Location in patent: Paragraph 0058; 0059
[3] Chemistry of Materials, 2010, vol. 22, # 18, p. 5258 - 5270
[4] Molecules, 2010, vol. 15, # 8, p. 5561 - 5580
[5] Patent: WO2014/89324, 2014, A1. Location in patent: Paragraph 0234
