ChemicalBook CAS DataBase List 69235-50-3

69235-50-3

Name	Acriflavine hydrochloride
CAS	69235-50-3
Molecular Formula	C27H28Cl4N6
MDL Number	MFCD00069039
Molecular Weight	578.363
MOL File	69235-50-3.mol

Chemical Properties

Melting point	240-247°C
bulk density	380kg/m3
storage temp.	Store at -20°C
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Water Solubility	Soluble in water
form	Powder
color	Orange-red to red-brown
PH	1.0 (20°C, 10g/L in H2O)
Merck	14,123
Stability:	Hygroscopic, Light Sensitive

Safety Data

RIDADR	3077
Autoignition Temperature	>190°C
HS Code	2933.99.8290
HazardClass	9
PackingGroup	III

Hazard Information

Uses

Acriflavine is an topical antiseptic agent and has also been used for the treatment of external fungal infections. Dyes and metabolites.

in vivo

Acriflavine (8 mg/kg; intraperitoneal injection; once a day; 13 administrations) hydrochloride inhibits tumor growth and angiogenesis in NOG mice bearing large HSR-GBM1-Luc cell-derived xenografts^[3].
Acriflavine (8 mg/kg; intraperitoneal injection; once a day; 15 administrations) hydrochloride inhibits tumor growth in NOG mice bearing small HSR-GBM1-Luc cell-derived xenografts^[3].
Acriflavine (8 mg/kg; intraperitoneal injection; once a day; 10 days of administration) hydrochloride reduces the development of chronic myeloid leukemia and the maintenance of leukemia stem cells in C57BL/6J-CD45.1 mice transplanted with BCR/abl-transduced bone marrow cells^[5].
Acriflavine (100 mg/kg orally; 5-15 mg/kg intramuscularly; once a day orally, twice a day intramuscularly; 6 days of administration) hydrochloride inhibits the replication of SARS-CoV-2 in the brain and lungs of K18-ACE2 transgenic mice^[6].

Animal Model:	NOG mice (male and female, 6-8-week-old) with HSR-GBM1-Luc cell - derived xenografts (subcutaneous injection of?HSR-GBM1-Luc cells into the left and right flanks)^[3].
Dosage:	8 mg/kg
Administration:	Intraperitoneal injection, once a day, 13 times or 15 times
Result:	Inhibited tumor growth. Also reduced tumor microvessel density, indicating inhibition of tumor vascularization.

Animal Model:	C57BL/6J-CD45.1 mice (8-10-week-old) with BCR/abl-induced chronic myeloid leukemia (retroviral transduction of BCR/abl into bone marrow cells and transplantation into recipient mice)^[5]
Dosage:	8 mg/kg
Administration:	Intraperitoneal injection, once a day, 10 days
Result:	Reduced splenomegaly, lung infiltrate with myeloid cells, and white blood cell count in peripheral blood. Decreased the percentage and number of?GFP⁺/CD34^-/LSK cells in bone marrow, indicating a reduction in leukemia stem cells.

Animal Model:	K18-ACE2 transgenic mice (female, 8-10-week-old) infected with SARS-CoV-2 (intranasal infection with the virus)^[6]
Dosage:	100 mg/kg, 5 mg/kg or 15 mg/kg
Administration:	Oral administration once a day, intramuscular injection twice a day, 6 days
Result:	Blocked the infection in the brain and significantly reduced the viral load in the lungs. The effect was more pronounced with oral administration.

storage

Store at -20°C

Supplier

TCI (Shanghai) Development Co., Ltd.

Telephone021-67121386

Websitehttps://www.tcichemicals.com/CN/zh/

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 15026964105

Websitehttps://www.shyuanye.com

9ding chemical ( Shanghai) Limited

Telephone021-021-52271985 17721149837

Websitehttp://www.9dingchem.com

Aikon International Limited

Telephone025-66113011 19370895928

Websitehttp://www.aikonchem.com

Shanghai Kaiwei Chemical Technology Co., Ltd.

Telephone021-58461859 15821823057

Websitehttp://www.aivichem.com

Shanghai Haohong Pharmaceutical Co., Ltd.

Telephone400-8210725 4008210725

Websitehttps://www.leyan.com/

Bide Pharmatech Ltd.

Telephone400-1647117 13681763483

Websitehttps://www.bidepharm.com/

Shanghai Maclean Biochemical Technology Co., LTD

Telephone021-50706066 15221275939

Websitehttp://www.macklin.cn/

Meryer (Shanghai) Chemical Technology Co., Ltd.

Telephone 18621169109

Websitehttp://www.x-labseek.com/

Beijing Solarbio Science & Tecnology Co., Ltd.

Telephone010-50973130 17801761073

Websitehttps://www.solarbio.com/

Shanghai Jieshikai Biotechnology Co. , Ltd.

Telephone021-57520305 13795461237

Websitehttps://www.jskchem.com

Taizhou Zhongzhi Biotechnology Co., Ltd

Telephonezhongzhipharma@126.c 15066129350

Website

LGC Science (Shanghai) Ltd.

Telephone17717235263 17717235263

Websitehttps://www.lgcstandards.com/CN/en/

1of3

Related Products

Send Inquriy