ChemicalBook CAS DataBase List 69198-10-3

69198-10-3

Name	Metronidazolehydrochloride
CAS	69198-10-3
Molecular Formula	C6H9N3O3.ClH
Molecular Weight	207.616
MOL File	69198-10-3.mol

Chemical Properties

Contact allergens

Metronidazole is a nitro-5-imidazole compound with antiprotozoal and antibacterial properties. Topical exposure may induce allergic contact dermatitis. Sensitization is mainly observed with the treatment of rosacea and rarely occurs from handling of tablets in nurses. Systemic intake may provoke fixed drug eruption.

Hazard Information

Definition

ChEBI: A hydrochloride salt resulting from the mixture of equimolar amounts of metronidazole and hydrogen chloride.

Uses

Metronidazole hydrochloride (SC 326421) is an orally active nitroimidazole antibiotic, can be used to research anaerobic infections. Metronidazole hydrochloride can cross blood brain barrier and results inflammation and skeletal muscle contraction under long-term application[1][2][3][4].

in vivo

Metronidazole hydrochloride (135 mg/kg/d; p.o.; 28 d) can cross the blood brain barrier, and exhibits neurotoxicity under long term administration in rats^[3].
Metronidazole hydrochloride (1 g/L; p.o.; 4 weeks) results skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation^[4].

Animal Model:	Sprague-Dawley (SD) rats (200-220 g)^[3]
Dosage:	135 mg/kg
Administration:	Oral gavage; once daily; 28 days
Result:	Caused inflammatory markers increasing, including iNOS, eNOS, Bax and caspase 3 protein expressions increasing and caused oxidative stress damage in brain tissue, with MDA content rising.

Animal Model:	SPF C57Bl/6J mice (6-7 months old)^[4]
Dosage:	1 g/L (full dose)
Administration:	Oral gavage; provided with drinking water for 4 weeks, changed twice weekly
Result:	Resulted the muscle core clock and effector genes Cry2, Ror-β, E4BP4, PP ARγ and adiponectin expression increasing. Decreased hind limb muscle weight and resulted in smaller fibers in the tibialis anterior muscle.

References

[1] Scully BE. Metronidazole. Med Clin North Am. 1988 May;72(3):613-21. DOI:10.1016/s0025-7125(16)30761-1
[2] Dhurga DB, et al. Granular Formation during Apoptosis in Blastocystis sp. Exposed to Metronidazole (MTZ). PLoS One. 2016 Jul 29;11(7):e0155390. DOI:10.1371/journal.pone.0155390
[3] Chaturvedi S, et al. Mechanistic exploration of quercetin against metronidazole induced neurotoxicity in rats: Possible role of nitric oxide isoforms and inflammatory cytokines. Neurotoxicology. 2020 Jul;79:1-10. DOI:10.1016/j.neuro.2020.03.002
[4] Manickam R, et al. Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism. Int J Mol Sci. 2018 Aug 16;19(8):2418. DOI:10.3390/ijms19082418

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