6903-79-3

Aplodan,Simes,Italy,1968

ChEBI: Creatinolfosfate is a phosphoethanolamine.

In a reactor put 80 kg of polyphosphoric acid having the following composition: H5P3O10 - 60%; (HPO3)6 - 10%; H4P2O7 - 15%; (HPO3)x - 10%; total content in P2O5 about 83%; this is heated to about 160°C.
Then 360 kg of creatinol phosphate are added to the polyphosphoric acid; continue to heat for about two hours under vacuum until the reaction water is eliminated.
The molten mass is then poured into ethanol at 95°C, the solution cooled down to 10°C and the precipitated product separated by centrifugation. The resulting product is dissolved in the minimum quantity of warm water and the solution poured into ethanol.
Thus 297 kg of the phosphoric ester of the creatinol are obtained having these characteristics: MP 240°C to 243°C.

Cardiotonic