Description
Benfuresate is a post-emergence herbicide. It has a moderate aqueous solubility and is relatively volatile. It is not persistent in soil systems but not normally persistent in water. It has a low mammalian toxicity and a low potential for bioaccumulation. It is relatively non-toxic to birds but moderately toxic to honeybees and most aquatic organisms.
Chemical Properties
Furosemide original drug purity ≥95%, melting point 32~35℃. Pure product is gray-white crystals (industrial product is dark brown highly viscous solution), with a slight odor, melting point 30.1 ℃. Vapor pressure:1.43mPa( 20℃),2.78mPa(25℃). Relative density:0.957, Kow lgP=2.41(20℃). Solubility in water 261mg/L(25℃). Solubility in organic solvents (g/L): acetone>1050, dichloromethane>1220, toluene>1040, methanol>980, ethyl acetate>920, cyclohexane51, n-hexane15.3. Stable in aqueous solution placed at 37°C, pH 5.0, 7.0, 9.2 for 31d. 0.1mol/L sodium hydroxide DT50 in aqueous solution is 12.5d. flash point 37.5°C (determined by Abel-Pinsky method), non-flammable.
Uses
Benfuresate may be used as a reference standard in the determination of the analyte in water and urine samples by an analytical method based on coupling photo-induced chemiluminescence in a multicommutation continuous flow methodology.', 'Refer to the productμs Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Definition
ChEBI: Benfuresate is a member of benzofurans.
Production Methods
Benfuresate is produced through a multi-step chemical synthesis involving sulfonation and esterification of a benzofuran derivative. The process begins with the preparation of 2,3-dihydro-3,3-dimethylbenzofuran, which is then reacted with ethanesulfonyl chloride in the presence of a base such as triethylamine to form the ethanesulfonate ester. This reaction typically occurs in an organic solvent under controlled temperature conditions to ensure selectivity and minimize side reactions.
Mechanism of action
Inhibits lipid synthesis. It acts by inhibiting the synthesis of fatty acids in plants, leading to the disruption of cell membranes and ultimately causing the death of the targeted weeds.
