67979-25-3

Aurantioobtusin is an anthraquinone originally isolated from Cassia seeds with diverse biological activities. It inhibits rat lens aldose reductase (RLAR) in vitro (IC₅₀ = 13.6 μM). Aurantioobtusin (10 and 100 μM) activates the aryl hydrocarbon receptor (AhR) in a concentration-dependent manner. It inhibits rat platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), ADP, and collagen. Aurantioobtusin induces vasorelaxation in isolated precontracted rat mesenteric artery rings, an effect that is inhibited by the PI3K inhibitor LY290042 or inhibition of endothelial nitric oxide synthase (eNOS). It is larvicidal against A. gambiae mosquitoes (LD₅₀ = 10 ppm).

Derived from the dried mature seeds of Cassia or Cassia minor, an annual herbaceous plant of the Leguminosae family

A compound found in herbal remedies, believed to have an effect on blood platelet aggregation and lower blood lipid count

ChEBI: A trihydroxyanthraquinone that is 1,3,7-trihydroxy-9,10-anthraquinone which is by methoxy groups at positions 2 and 8, and by a methyl group at position 6.

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[2] YOSHIAKI AMAKURA. Characterization of natural aryl hydrocarbon receptor agonists from cassia seed and rosemary.[J]. Molecules, 2014, 19 4: 4956-4966. DOI: 10.3390/molecules19044956
[3] HYE SOOK YUN-CHOI  Michio T  Jae Hoon Kim. Potential Inhibitors of Platelet Aggregation from Plant Sources, V. Anthraquinones from Seeds of Cassia obtusifolia and Related Compounds[J]. Journal of Natural Products , 1990, 53 3: 630-633. DOI: 10.1021/np50069a014
[4] SHUZHEN LI . Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats[J]. Journal of pharmacological sciences, 2015, 128 3: Pages 108-115. DOI: 10.1016/j.jphs.2015.05.006
[5] VALENTINE C MBATCHOU. Mosquito larvicidal activity of Cassia tora seed extract and its key anthraquinones aurantio-obtusin and obtusin.[J]. Parasites & Vectors, 2017: 562. DOI: 10.1186/s13071-017-2512-y