6792-09-2

New use of neoaconitrile in the preparation of medicaments for preventing and/or treating myocardial fibrosis and chronic heart failure caused by myocardial fibrosis

Mesaconinean, the active ingredient extracted from Aconitum carmichaelii Debx., has cardiovascular effects.

1) Inhibit or reverse myocardial tissue fibrosis; 2) Improve abnormal cardiac remodeling; 3) Improve cardiac dysfunction; 4) Improve the survival rate of mice with chronic heart failure caused by myocardial fibrosis; 5) Fight against myocardial tissue inflammation; 6 ) Inhibition of cardiomyocyte apoptosis; 7) Myocardial enzyme activity in dead mice, and its mechanism of action is related to inhibiting myocardial tissue inflammation and fibrosis caused by adriamycin and resisting cardiomyocyte apoptosis.