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β-Chlornaltrexamine dihydrochloride (β-CNA dihydrochloride) is a potent long-term opioid receptor blocker. β-Chlornaltrexamine dihydrochloride can effectively block the inhibitory effect of κ opioid receptor agonists on dopamine release. β-Chlornaltrexamine dihydrochloride can be used to study the mechanism of pain perception[1].

[1] Reichard K L, et al. Regulation of kappa opioid receptor inactivation depends on sex and cellular site of antagonist action[J]. Molecular Pharmacology, 2020, 98(5): 548-558. DOI:10.1124/molpharm.120.000124