66611-26-5

RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion[1].

ChEBI: 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole is a member of indoles.

5-HT_1B Receptor: 0.38 nM (Ki); 5-HT_1A Receptor: 2.5 nM (Ki)

Store at -20°C

[1] Aronsen D, et, al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep; 124: 1-4. DOI:10.1016/j.pbb.2014.05.008
[2] Brazell MP, et, al. The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br J Pharmacol. 1985 Sep; 86(1): 209-16. DOI:10.1111/j.1476-5381.1985.tb09451.x