ChemicalBook CAS DataBase List 66455-27-4

66455-27-4

Name	GLYCOPROTEIN, ALPHA1-ACID HUMAN
CAS	66455-27-4
Molecular Formula	NULL
MDL Number	MFCD00131224

Chemical Properties

storage temp.	2-8°C
solubility	H₂O: 10 mg/mL, clear, colorless
form	Lyophilized
biological source	human plasma
Merck	13,8018
Specific Activity	88-120nmol/min·mg

Safety Data

Hazard Codes	B
Safety Statements	22-24/25 less more
WGK Germany	3
F	10-21
Storage Class	11 - Combustible Solids

Raw materials And Preparation Products

Hazard Information

Chemical Properties

This product is a brown or brownish powder with a slight characteristic odor and is odorless. The melting point is 120°C. It is soluble in water but virtually insoluble in methanol, chloroform, benzene, cyclohexane, etc.
This product is a proteoglycan with a protein content of 25%-30%. It exhibits anti-tumor activity both in vivo and in vitro. Its anti-tumor effect is related to its ability to stimulate the body's anti-tumor immune function. Yunzhi polysaccharide can enhance cellular immunity and promote delayed-type hypersensitivity reactions and lymphocyte proliferation. It can also increase the production of interferon, interleukin 1 and 2, and prostaglandins. It can also restore low IgG and IgM levels in tumor-bearing animals to normal. However, it does not enhance the phagocytic function of macrophages in tumor-bearing animals.
After oral administration, Yunzhi polysaccharide is absorbed from the digestive tract and distributed throughout organs and tumor tissues. Approximately 70% is eliminated from the body within 24 hours, primarily through the respiratory tract in the form of carbon dioxide.

Uses

GLYCOPROTEIN, ALPHA1-ACID HUMAN was used to study nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine.

Uses

α1-Acid glycoprotein from human plasma has been used:

as negatively charged protein to investigate the adsorption processes onto the surface of polyelectrolyte multilayers
to incubate plates coated with purified antiserum in the study to investigate its serum concentration by ELISA
to study the effect of its different concentrations on the antiviral activity of human immunodeficiency virus (HIV) protease inhibitors

General Description

α-1-Acid glycoprotein (AGP)/orosomucoid (ORM), a glycoprotein has a molecular weight of 41-43kDa. It is considered as one of the important acute phase proteins in humans and rats. AGP may belong to the lipocalin family.

Biochem/physiol Actions

α1-Acid glycoprotein possesses immunomodulating effects. It has the ability to bind to acidic drugs, like phenobarbital.

Purification Methods

Purify the glycoprotein 1 acid by passage through a carboxymethyl cellulose column, then through a Sephadex G-25 column. [Aronson et al. J Biol Chem 243 4564 1968.]

Supplier

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