65569-29-1

Name	Cloxacepride
CAS	65569-29-1
Molecular Formula	C22H27Cl2N3O4
MDL Number	MFCD00867084
Molecular Weight	468.37
MOL File	65569-29-1.mol

Synonyms

Cloxacepride 5-Chloro-4-[(4-chlorophenoxy)acetylamino]-N-[2-(diethylamino)ethyl]-2-methoxybenzamide 5-Chloro-4-[[(4-chlorophenoxy)acetyl]amino]-N-[2-(diethylamino)ethyl]-2-methoxybenzamide Benzamide, 5-chloro-4-[[2-(4-chlorophenoxy)acetyl]amino]-N-[2-(diethylamino)ethyl]-2-methoxy-

show less show more

Hazard Information

Uses

Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity[1][2].

in vivo

Oral ED₅₀ values for cloxacepride of 46-49 mg/kg were comparable to that of theophylline (HY-B0809) and to an intravenous injection of 2 mg/kg of disodium chromoglycate (DSCG) followed by immediate challenge^[1].
Cloxacepride has anti-PCA activity when administered orally 15 or 60 min before antigenic challenge^[1].

References

[1] Metz G, et al. Cloxacepride and related compounds: a new series of orally active antiallergic compounds. J Med Chem. 1983 Jul;26(7):1065-70. DOI:10.1021/jm00361a022
[2] Gigl G, et al. Calmodulin antagonism: a pharmacological approach for the inhibition of mediator release from mast cells. Cell Calcium. 1987 Oct;8(5):327-44. DOI:10.1016/0143-4160(87)90008-x
[3] Friedrich G, et al. Inhibitory effect of cloxacepride on compound 48/80-induced histamine and serotonin release from rat mast cells. Arch Int Pharmacodyn Ther. 1984 Feb;267(2):264-8. PMID:6201147

Spectrum Detail

Cloxacepride(65569-29-1)¹HNMR

Supplier

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Beijing Boorsen Biotechnology Co., Ltd

Telephone400-901-9800 18611424007

Websitehttp://www.bioss.com.cn/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Shanghai Amole Biotechnology Co., Ltd.

Telephone13370042665 18916960931

Websitehttps://www.amole.com.cn/

Related Products

55302-96-0 2401-24-3

614-39-1 54143-57-6

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy